It was pretty clear from the get go this was Uncharted. I doubted myself once I saw the planes fly overhead bombing a middle eastern city. However, I thought for sure that it was Chloe, and sure enough the finale of the trailer not only reintroduced Chole but showed off Nadine as the 'protagonists' of this story. It'll be interesting to see if this ties into the main Uncharted stories at all, although it likely doesn't, nor does it need to. It'll be fun to run around as two badass women throughout a campaign in this universe.
I'll also be interested to see if this is a more stealth heavy game. The clip, although largely cinematic, seemed to indicate stealth may be a more important than it was in Uncharted 4.
I'm also curious if we just get to play as Chloe the entire time or if we are able to switch to Nadine. I hope Nadine is more than just a Sam or Sully in this game. Only time will tell.